United have lost their opening two games of a Champions League group for the first time.
New goalkeeper Andre Onana had another night to forget in Europe.
Rasmus Hojlund twice gave United the lead, but Galatasaray fought back to win away from home in the Champions League for the first time in 10 years thanks to goals from Wilfried Zaha, Kerem Akturkoglu and Mauro Icardi.
Onana accepted responsibility after his error allowed Bayern Munich to open the scoring in United’s 4-3 defeat in Germany to start Group A.
The Cameroonian was at fault once more for the move that saw Casemiro sent-off for conceding a penalty on 77 minutes.
Icardi missed the spot-kick, but quickly made amends to score the winner against 10 men.
United’s 1-0 defeat at home to Crystal Palace on Saturday meant Erik ten Hag’s men are also off to their worst ever start to a Premier League season with four defeats from seven games.
Progress to the last 16 of the Champions League now looks an uphill task.
Bayern beat FC Copenhagen 2-1 away to move onto six points with Galatasaray four clear of United with four games to play.
AFP
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