The call was contained in a statement signed by its spokesman, Emma Powerful, on Friday.
Powerful said Kanu’s health has deteriorated inside the detention facilities.
The statement read, “IPOB is bringing to the notice of the international community that the Federal Government and her judiciary have planned a systematic murder of Mazi Nnamdi Kanu, using the instrumentality of their fraudulent judicial system.
“Our leader was kidnapped and extraordinarily renditioned to Nigeria and detained for almost three years in DSS solidarity confinement in Abuja. His health has deteriorated inside the detention facilities, and DSS has been using experimental drugs and practices for his serious health issues.
“The DSS lacks proper medical facilities to take care of his falling heart conditions.”
Powerful insisted that the IPOB leader committed no crime.
“Igbo politicians must use this little opportunity they have wisely to ensure that the Federal Government who want to suffocate Kanu gradually inside DSS solitary confinement as he suffers from a terminal heart and lung disease does not do so.
“Irrespective of all the judicial abracadabra, the Federal Government must ensure that our leader must not die in their hands nor die shortly after his release. Kanu’s life is a trigger that can consume Nigeria and the generations unborn.
“Those who intend to tag us terrorists and those who are friends of Nigeria must advise the Federal Government to release Kanu healthy as the Appeal Court Justices declared. The same peaceful IPOB seen worldwide is capable of taking on Nigeria when the need arises. This is not a threat but a promise,” he added.
Earlier this week, some South-East members of the House of Representatives called for discontinuing Kanu’s trial.